ERA Chair Holder Group
Enhancing Research in Ageing at the University of Coimbra
Lino Ferreira
lino.ferreira@uc.pt | ORCID
Activity:
The research group aims to better understand and treat cardiovascular ageing. To tackle this question, the group is using novel in vitro cell/tissue models from human stem cells, and particularly induced pluripotent stem cells (iPSCs), isolated from patients with accelerated ageing processes, performing drug screening programs using both small molecules and RNA-based drugs, and developing advanced systems to delivery efficiently the anti-ageing drugs.
Relevant publications:
Pitrez, PR, Estronca, L, Vazão, H, Harhouri, K, Thornton, D, Navarro, C, Egesipe, A-L, Lévy, N, Magalhães, JP, De Sandre-Giovannoli, A, Nissan, X, Rosell, A, Ferreira L. “A chip to study the vulnerability of progeroid smooth muscle cells to flow shear stress”. Nature Communications 2020, 11, 4110.
Blersch, J, Francisco, V, Rebelo, C, Jimenez, A, Henriques-Antunes, H, Gonzato, C, Pinto, S, Liedl, K, Haupt, K, Ferreira, L. “A light-activatable nanoparticle library for the controlled release of non-coding RNAs”. Angew Chem Int Ed 2020, 59(5), 1985-1991.
Abreu, R, Fernandes, H, Martins, PC, Sahoo, S, Emanueli, C, Ferreira, L. “Native and engineered extracellular vesicles for cardiovascular therapeutics”. Nature Reviews Cardiology 2020,17, 685–697.
Henriques-Antunes, H, Cardoso, RMS, Zonari, A, Correia, J, Leal, EC, Jimenez-Balsa, A, Lino, M, Barradas, A, Kostic, I, Gomes, C, Karp, JM, Carvalho, E, Ferreira, L. The kinetics of small extracellular vesicle delivery impacts skin tissue regeneration. ACS Nano 2019, 13, 8, 8694–8707.
Lino MM, Simões S, Vilaça A, Antunes H, Zonari A, Ferreira L. “Modulation of angiogenic activity by light-activatable nanocarriers carrying miRNAs”. ACS Nano 2018, 12(6), 5207-5220.
