Publications

2024

Amorim R, Magalhães C, Benfeito S, Cagide F, Tavares L, Santos K, Sardão V, Datta S, Cortopassi G, Baldeiras I, Jones J, Borges F, Oliveira P, Teixeira J. Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism. Biochemical Pharmacology. 2024.

2023

Almeida S, Santos L, Sampaio-Ribeiro G, Ferreira H, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro A, Paiva, A, Martins-Marques T, Teixeira P, Almeida R, Casanova J, Girão H, Abrunhosa A, Gomes C.Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling. Journal of Experimental & Clinical Cancer Research. 2023 Nov 30.

Santiago J, Silva J, Santos M, Fardilha M. Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile. Biomedicines. 2023 Oct 28.

Ferreira-Marques M, Carvalho A, Franco AC, Leal A, Botelho M, Carmo-Silva S, Águas R, Cortes L, Lucas V, Real AC, López-Otín C, Nissan X, de Almeida LP, Cavadas C, Aveleira CA. Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome. Aging Cell. 2023 Oct 19.

Pedrosa A, Furtado G, de Barros MP, Bachi ALL, Ferreira JP, Sardão VA, et al.The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglobin Levels in Type 2 Diabetes Patients. Diabetology. 2023 Dec 28;4(1):11–8.

Carvalhas-Almeida C, Cavadas C, Álvaro AR. The impact of insomnia on frailty and the hallmarks of aging. Aging Clin Exp Res. 2023 Dec 30;35(2):253–69.

Silva DF, Cavadas C. Primary cilia shape hallmarks of health and aging. Trends Mol Med. 2023 Jul;29(7):567–79.

Lucas V, Cavadas C, Aveleira CA. Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies. Pharmacol Rev. 2023 Jul;75(4):675–713.

Bessa C, Loureiro JB, Barros M, Isca VMS, Sardão VA, Oliveira PJ, et al. Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator. Int J Mol Sci. 2023 Mar 16;24(6):5710.

Amorim R, Magalhães CC, Borges F, Oliveira PJ, Teixeira J. From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria. Biology (Basel). 2023 Apr 14;12(4):595.

Neves D, Salazar IL, Almeida RD, Silva RM. Molecular mechanisms of ischemia and glutamate excitotoxicity. Life Sci. 2023 Sep;328:121814.

Castelão-Baptista JP, Valente SA, Canário S, Oppolzer D, Barros A, Venâncio C, et al. Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity. Nutrients. 2023 Feb 12;15(4):924.

Pinho SA, Anjo SI, Cunha-Oliveira T. Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics. Antioxidants. 2023 May 10;12(5):1072.

Diniz MS, Grilo LF, Tocantins C, Falcão-Pires I, Pereira SP. Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb. Metabolites. 2023 Jul 13;13(7):845.

Marques-Carvalho A, Sardão VA, Kim HN, Almeida M. ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens. Front Endocrinol (Lausanne). 2023 Apr 20;14.

Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, et al. Extracellular vesicles improve GABAergic transmission in Huntington’s disease iPSC-derived neurons. Theranostics. 2023;13(11):3707–24.

Marote A, Santos D, Mendes-Pinheiro B, Serre-Miranda C, Anjo SI, Vieira J, et al. Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture. Stem Cell Rev Rep. 2023 Jan 24;19(1):248–63.

Simões AP, Portes MAM, Lopes CR, Vanz F, Lourenço VS, Pliássova A, et al. Adenosine A2A receptors control generalization of contextual fear in rats. Transl Psychiatry. 2023 Oct 12;13(1):316.

Carvalho C, Pires JF, Moreira PI, Raimundo N. Disrupted cellular quality control mechanisms in aging. In: Aging. Elsevier; 2023. p. 359–84.

Marques-Carvalho A, Silva B, Pereira FB, Kim HN, Almeida M, Sardão VA. The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism. bioRxiv.

2022

Ribeiro RFN, Pereira D, de Almeida LP, Silva MMC, Cavadas C. SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders. Aging Clin Exp Res. 2022 Oct 28;34(12):2963–76.

Musa M, Dionisio PA, Casqueiro R, Milosevic I, Raimundo N, Krisko A. Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans. Life Sci Alliance. 2023 Jan;6(1):e202201737.

Neves M, Grãos M, Anjo SI, Manadas B. Modulation of signaling pathways by DJ-1: An updated overview. Redox Biol. 2022 May;51:102283.

Francisco S, Martinho V, Ferreira M, Reis A, Moura G, Soares AR, et al.The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging. Int J Mol Sci. 2022 Mar 17;23(6):3232.

Magaña JC, Deus CM, Giné-Garriga M, Montané J, Pereira SP. Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease. Biomedicines. 2022 Dec 12;10(12):3228.

Lopes MM, Paysan J, Rino J, Lopes SM, Pereira de Almeida L, Cortes L, et al. A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification. Gene Ther. 2022 Dec 1;29(12):665–79.

Upmanyu N, Jin J, Emde H von der, Ganzella M, Bösche L, Malviya VN, et al. Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron. 2022 May;110(9):1483-1497.e7.

Costa DG, Almeida C, Cavadas C, Carmo-Silva S. A look on food intake and satiety: from humans to rodent models. Nutr Rev. 2022 Jul 7;80(8):1942–57.

Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, et al. Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson’s disease. Eur J Clin Invest. 2022 Oct 13;52(10).

Carmo-Silva S, Ferreira-Marques M, Nóbrega C, Botelho M, Costa D, Aveleira CA, et al. Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes. J Mol Endocrinol. 2023 Jan 1;70(1).

Ferreira RM, Figueiredo J, Pinto-Ribeiro I, Gullo I, Sgouras DN, Carreto L, et al. Activation of Laminin γ2 by Helicobacter pylori Promotes Invasion and Survival of Gastric Cancer Cells With E-Cadherin Defects. J Infect Dis. 2022 Dec 13;226(12):2226–37.

Milosevic I, Knight JD. Exocytotic SNARE complex assembly, disassembly, and regulation. In: Exocytosis: From Molecules to Cells. IOP Publishing; 2022. p. 3-1-3–32.

Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, et al. Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life Sci Alliance. 2022 Mar;5(3):e202101185.

2021

Low E, Alimohammadiha G, Smith LA, Costello LF, Przyborski SA, von Zglinicki T, et al. How good is the evidence that cellular senescence causes skin ageing? Ageing Res Rev. 2021 Nov;71:101456.

Milosevic I, Cousin MA. Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases. Journal of Cell Biology. 2021 Dec 6;220(12).

Deus CM, Pereira SP, Cunha-Oliveira T, Teixeira J, Simões RF, Cagide F, et al. A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson’s disease patients. Redox Biol. 2021 Sep;45:102037.