Portal
structures
- ACOI - Coimbra Collection of Algae
- Chemical Engineering and Renewable Resources for Sustainability (CERES)
- Coimbra Laser Lab (CLL)
- Cytogenetics and Genomics Laboratory
- Earth Observation Laboratory (eoLab)
- Functional Genomics and Sequencing - UCGenomics
- GeoSedUC Services
- Instituto de Ciências Nucleares Aplicadas à Saude (ICNAS)
- Laboratory for Advanced Computing
- Laboratório de Anatomia Patológica e Patologia Molecular
- Laboratório de Engenharia de Fogo da Universidade de Coimbra (FIRElab)
- Laboratório de Microscopia Ótica Avançada (LMOA)
- Laboratório de Neurogenética
- Laboratório de Radioatividade Natural (LRN)
- Marefoz Laboratory
- Mitochondrial Biomedicine and Theranostics Laboratory
- Trace Analysis and Imaging Laboratory (TAIL)
- UC-NMR | Nuclear Magnetic Resonance Facility
- Unidade de Psicologia Clínica Cognitivo-Comportamental (UPC³)
- University of Coimbra Bacteria Culture Collection (UCCCB)
- ViraVector
- Water Microbiology Laboratory
- iLAB - Microscopy and Bioimaging Lab
Scientific domains
- Agricultural Biotechnology
- Agricultural Sciences
- Biochemistry
- Biological Sciences
- Biomaterials
- Bioproducts, Biomaterials, Bioplastics, Biofuels, Bio-derived Bulk and Fine Chemicals and Bio-derived Novel Materials
- Cell Biology
- Chemical Engineering
- Chemical Engineering
- Chemical Process Engineering
- Chemical Sciences
- Civil Engineering
- Civil Engineering
- Construction Engineering
- Earth & Related Environmental Sciences
- Engineering and Technology
- Environmental Biotechnology
- Environmental Engineering
- Exact Sciences
- Forensic Science
- Genetics and Heredity
- Health Care Sciences and Services
- Health sciences
- Health-related Biotechnology
- Human Genetics
- Industrial Biotechnology
- Medical & Health Sciences
- Medical Biotechnology
- Medical Engineering
- Medical geology
- Medicinal Chemistry
- Microbiology
- Molecular Biology
- Molecular Pathology
- Nanotechnology
- Natural Sciences
- Natural radioactivity
- Neurosciences
- Oncobiology
- Pharmacology and Pharmacy
- Physical Sciences
- Psychology
- Reproductive Biology
- Training & Support
Techniques
- 3D imaging
- Alpha spectrometry in the range (0; 10) MeV and energy resolution lower than 20 keV
- Alpha spectroscopy with a high efficiency ionization chamber (1 cpm at 20 Bq/m3)
- Array Comparative Genomic Hybridization - Array-CGH
- Atomic Force Microscopy
- Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR | FTIR)
- Automatic Sanger sequencing
- Automatic microscopic analysis of traces on passive detectors
- C banding
- Calculation from other tests
- ChIP (chromatin immunoprecipitation assay)
- Chef & Ion Torrent S5 (NGS)
- Circulating free DNA (cfDNA) extration
- Colocalisation assays
- Column chromatography
- Computação GPU
- Consultas em grupo (modalidade online ou presencial)
- Consultas individuais (online ou presenciais)
- Contact Angle Determination
- Conventional PCR
- Crucible method
- Cultivation in WLD medium
- Cytogenetics
- DNA extraction
- Differential Scanning Calorimetry (DSC)
- Differential electric conductivity
- Differential scanning calorimetry (DSC)
- Dynamic Light Scattering (DLS)
- Dynamic Light Scattering (DLS)
- EBV based immortalization
- EEG
- Electric resistivity
- Electron Transport (ET)
- Elemental Analysis - CHNS
- Elemental Analysis - O
- Elemental Analysis - S
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Extracellular flux analyses (bioenergetics)
- FISH - Fluorescence in situ Hybridization
- FRAP - fluorescence recovery after photobleaching
- FRAXA by PCR
- FRAXA by Triplet Repeat Primed PCR
- Flame Atomic Absorption Spectroscopy (FAAS)
- Fluorescence imaging with optical seccioning
- Fluorescence in situ hybridization
- Fluorescence microplate reading
- Fluorescence microscopy
- FormacsHT High Temperature Catalytic Combustion
- Fourier-Transform Infrared Spectroscopy | Mid-infrared Region (FTIR | MIR)
- Fourier-Transform Infrared Spectroscopy | Near-infrared Region (FTIR | MIR)
- G banding
- Gas Chromatography (GC)
- Gas Chromatography with Flame-Ionization Detection (GC | FID)
- Gas Chromatography with Mass-Spectrometry detection (GC | MS)
- Gas chromatography (GC)
- Genetic Analyser 3130 - ThermoFisher (Sanger sequencing)
- Graphite Furnace Atomic Absorption Spectroscopy (GFAAS)
- Gravimetric analysis
- Gravimetry
- Hall effect
- Hematoxylin-eosin
- Hemocytometer count
- High Performance Liquid Chromatography (HPLC)
- High Performance Liquid Chromatography coupled with an Evaporative Light-Scattering Detector (HPLC | ELSD)
- High Performance Liquid Chromatography with Refractive Index Detector (HPLC-RID)
- High Performance Liquid Chromatography with Ultraviolet-Visible Detection (HPLC | Uv-Vis)
- High Performance Liquid Chromatography with electrochemical detection
- High Pressure Homogenizer (HPH)
- High resolution gamma-ray spectrometry in the energy interval (40;2800) keV
- High-performance liquid chromatography (HPLC).
- High-resolution NMR spectroscopy in liquid state
- Illimuna MiSeq (NGS)
- Imaging and neurotransmitter uncaging
- Imaging of live tissue sections
- Immunohistochemistry
- Imunoensaio enzimático (ELISA)
- Inductively coupled plasma mass spectrometry (ICP-MS)
- Inverse gas chromatography (IGC)
- Ion Chromatography (IC)
- Isotope Ratio Mass Spectrometry
- Karl Fischer Coulometric Titration
- Karl Fischer Volumetric Titration
- Laser Diffraction Spectroscopy (LDS)
- Liquid Scintillation Counting with Guard Compensation Technology (GCT) and Guard Background Reduction (BGO)
- Live cell imaging
- Long PCR (mtDNA)
- Luminometry
- Measurement of Surface Tension
- Methylation-Specific Multiplex Ligation-dependent Probe Amplification - MS-MLPA
- Microtomy
- Modulated Differential Scanning Calorimetry (MDSC)
- Molecular Absorption Spectrometry
- Molecular cytogenetics
- Multiplex Ligation-dependent Probe Amplification - (MLPA)
- NGS - Next Generation Sequencing
- NOR banding
- Nanoparticle tracking analysis (NTA)
- Next Generation Sequencing (NGS)
- Next generation sequencing - NGS
- Optical Microscopy
- PCR-RFLP
- PET
- PET Animal
- Parallel computing
- Photomanipulation experiments
- Polimerase Chain Reaction (PCR)
- Polymerase Chain Reaction (PCR)
- Potentiometric titration
- Potentiometry (pH electrode)
- Protein gel electrophoresis, western blotting
- Qualitative Real-Time PCR
- Quantitative fluorescent PCR (QF-PCR)
- Quantitative real-time Polymerase Chain Reaction (qPCR)
- Real-Time PCR
- Refractometer - Refractive Index (RI)
- Ressonancia 3T
- Ressonância Animal - 9.4T
- Restriction Fragment Lenght Polimorphism (RFLP)
- Rheology - Creep Recovery Test
- Rheology - Effects of Aging Time, Shear Rate, and Temperature
- Rheology - Shear Viscosity
- Rheology - Thixotropy
- Rheology - Viscoelastic Properties
- Rheology - Yield Stress
- SHG-Secong Harmonic Generation
- Sample preparation for microscopy
- Scanning Confocal Microscopy
- Scanning Electron Microscopy
- Scanning Electron Microscopy (SEM)
- Sequenciação de Sanger
- Short Tandem Repeat (STR-PCR)
- Simultaneous Differential Thermal Analysis (SDT)
- Specific heat (Cp)
- Spectral detection
- Spectrophotometry
- Spectrophotometry
- Spectrophotometry UV-visible
- Sputtering
- Staining digitizer
- Static Light Scattering (SLS)
- TMS
- Test for Helicobacter pylori
- Testing rate based on strain rate
- Testing rate based on stress rate
- Thermogravimetric Analysis (TGA)
- Thermogravimetry (TG)
- Thin-layer chromatography (TLC)
- Tissue Culture
- Tissue processing
- Transmission Electron Microscopy
- Triplet Repeat Primed PCR (TP-PCR)
- Ultra Low Level Liquid Scintillation Counting with anticoincidence guard detector and lead radiation shield
- Ultraviolet-Visible Spectrophotometry (UV | Vis)
- VSM magnetometry
- ViraVector - EVs isolation platform
- ViraVector - AAV innovative platform
- ViraVector - LV innovative platform
- ViraVector - Modified EVs innovative platform
- Viscosity - Capillary Viscometer
- Visualization
- Western blotting
- Widefield Microscopy
- X-ray diffraction (XRD)
- X-ray fluorescence spectroscopy (XRF)
- Y Chromosome Microdeletion Detection
- Zeta Potential
- digital droplet PCR (ddPCR)
Tags
- AAV
- ASBC and EBC methods
- ATR
- Acetic acid bacteria
- Adeno-associated viral vector
- Advanced Computing
- Aggregation
- Algae
- Alzheimer
- Alzheimer
- Amount of Water
- Análise Termogravimétrica (TGA)
- ApoE
- Artificial Intelligence
- Atomic Absorption
- BG11
- Bacteria
- Beer
- Big Data
- Biochemical analysis
- Bitterness
- Business intelligence
- C banding
- C9orf72
- CHNS-O
- CNV
- CYP450
- Carotenoids
- Cavernomas
- Centromeric
- Citogenética
- Clean room
- Colocalization
- Color
- Concrete materials
- Consultancy
- Contact Angle
- Contamination
- Copy number variations
- Cromatography
- Cryopreservation
- Culture media
- Cyanobacteria
- Cytogenetics
- DNA
- Deletions
- Demência
- Demência Frontotemporal
- Deposit
- Diagnóstico pré natal
- Differential Scanning Calorimetry (DSC)
- Doenças de Pequenos Vasos
- Duplications
- Dynamic Light Scattering (DLS)
- Dysmorphism
- EBC scale
- ELISA
- EV-AAVs
- EVs
- Earth Observation
- Elemental Analysis
- Empty capsids
- Epilepsia
- Esclerose Lateral Amiotrófica
- Esclerose Tuberosa
- Exosomes
- Extracelular vesicles
- Extracelular vesicles
- F/2
- FAAS
- FTIR
- Fatty acids
- Fire
- Flocculation
- Fluorescence microscopy
- Friedreich
- Full capsids
- Functional Genomics
- G banding
- GC
- GFAAS
- Gas Chromatography
- Gene
- Gene therapy
- Genetic Engineering
- Genome
- Genomics
- Glycolipids
- HPLC
- Hemocytometer
- High Performance Liquid Chromatography
- Huntington
- IGC
- Inborn errors of metabolism
- Ion Chromatography
- Ions
- Isolation
- Isolation
- Isótopos
- Karl Fischer
- LC
- LV
- Lactic acid bacteria
- Lentivirus
- Leucemia
- Light microscopy
- Live-imaging
- M7
- MHY
- MIDI
- Machado-Joseph
- Macroinvertebrados
- Magnetism
- Marker chromosome
- Metallic materials
- Methylation
- Microalgae
- Microanalysis
- Microbial Community
- Microorganisms
- Microplates
- Mitochondrial diseases
- Mixed culture
- Monitoring
- Monosaccharides
- Morphology
- Multiphoton microscopy
- Multiproposes certificates
- NGS
- NIPT
- NMR
- NMR 1D
- NMR 2D
- NOR banding
- Neural development
- Neural development diseases
- Neutral lipids
- Nutrients
- PCR
- Paraparésia Espástica
- Parkinson
- Particles
- Personalized Medicine
- Pharmacogenomics
- Phospholipids
- Pigments
- Polar lipids
- Polysaccharides
- Potentiometric titration
- Preservation
- Production
- Progranulémia
- Pure culture
- Purification
- Purity
- QF-PCR
- RAPD
- Rare diseases
- Recursos naturais
- Repicting
- Respiratory quinones
- Rheology
- Ring Chromosome
- S2T2
- SEM
- SRM scale
- Sanger
- Segurança alimentar
- Selective medium
- Sequencing
- Simultaneous Differential Thermal Analysis (SDT)
- Size
- Specific gravity
- Specific heat capacity (Cp)
- Spectroscopy
- Static Light Scattering (SLS)
- Strains
- Sub-telomerics regions
- Surface Tension
- Theragnostics
- Thermal Analysis
- Thin Layer Chromatography
- Thixotropy
- Titration
- Total acidity
- Total lipids
- Total reducing sugars
- Training
- Transcriptomics
- Tumores
- Ultracentrifugation
- Unbalanced chromosome rearrengement
- Uv-Vis
- Viral particles
- Viral titer
- Viral vectors
- Viscosity
- WLD medium
- Western blotting
- Whole Chromosome Painting - WCP
- Xanthophylls
- Yeast cell count
- Yeasts
- Z8
- Zeta Potential
- Zeta Potential
- análise de riscos
- array-CGH
- carbon-14
- cfDNA
- data analytics
- digital PCR
- fuel
- gamma radiation
- hemato oncology
- indoor air quality
- instrumentation
- ionizing radiation
- lentiviral vector
- lung cancer
- mitigation
- mitochondria
- mtDNA
- occupational health and safety
- pH
- radioactivity
- radionuclides
- radon
- remediation
- risk evaluation
- sampling
- sílica
- toc
- vexosomes
- water quality
206 available services
![](https://pages.uc.pt/site/assets/files/548458/acoi_algoteca_logo-01.png)
Culture medium
Ready-to-use culture media or concentrated reagent kits (BG11, M7, S2T2, F/2 with different salinities, LC, Z8, MHY) Soil and Sphagnum extract for M7, S2T2, and LC media. The composition of the culture medium is sent with the medium.
Deposit of microalgae and cyanobacteria
Public deposit of microalgae and cyanobacteria
Determination of monosaccharides (HPLC-RI)
Extraction, hydrolysis, identification, and quantification of monosaccharides from microalgae and cyanobacteria by high-performance liquid chromatography (HPLC-RI).
Determination of pigments (HPLC-DAD)
Extraction, identification and quantification of pigments from microalgae and cyanobacteria by high-performance liquid chromatography (HPLC-DAD)
Determination of the fatty acids profile (GC-FID)
Extraction, identification and quantification of fatty acids from microalgae and cyanobacteria by gas chromatography (GC-FID).
Determination of total lipid and lipid fractions
Extraction and quantification of total lipid from microalgae and cyanobacteria by gravimetric methods; separation and quantification of neutral lipids, glycolipids and phospholipids by column chromatography
Determination of total sugars
Extraction and quantification of total sugars of microalgae and cyanobacteria by gravimetric analysis and spectrophotometry
Genomic DNA of microalgae and cyanobacteria from the collection
Genomic DNA from microalgae and cyanobacteria from collection, minimum of 2 µg of DNA. Qualitative and quantitative assessment by spectrophotometry.
Isolation and preservation
Isolation and preservation of microalgae and cyanobacteria (routine subculture and cryopreservation)
Microalgae and cyanobacteria strains from the collection
Microalgae and cyanobacteria live strains
Taxonomic identification of microalgae and cyanobacteria
Taxonomic identification of microalgae and cyanobacteria using a polyphasic approach (microscopy, molecular biology, biochemistry).
![](https://pages.uc.pt/site/assets/files/966682/imagem1.png)
Determination of the Water content of a Sample - Karl Fischer
The Karl Fischer titration is a sensitive method to quantify the % water in various types of samples.
Elemental Analysis
Mass percentage (% m/m) quantification of carbon (C), hydrogen (H), nitrogen (N), sulfur (S) and oxygen (O) present in a sample.
Identification and Quantification of Ions
Quantitative and qualitative determination of ions (anions and cations).
Identification and/or Quantification of Compounds - Chromatographic Methods
Separation of the various components of a mixture, with the aim of identifying and quantifying these components.
Identification and/or Quantification of Compounds - Spectroscopic Techniques
Spectroscopic analysis methods consist of measuring the amount of radiation emitted or absorbed by molecules.
Rheology and Viscosity Analysis
Study of the deformational behavior and the flow of matter subjected to stress, under certain thermodynamic conditions over a period of time. It includes properties such as: elasticity, viscosity and plasticity.
Stability and Particle Size Tests
Determination of particle sizes (from 3 nm to 5000 μm). Aggregation, agglomeration and flocculation studies.
Studies of Surface Properties
Determination of surface chemical and physical properties.
Thermal Analysis
Study of the behavior of materials as a function of time or temperature, when heated, cooled or kept at a constant temperature.
![](https://pages.uc.pt/site/assets/files/548460/captura_de_ecra_2022-10-07-_a_s_15_32_07.png)
Chemical Reactivity at Low-Temperatures
Investigations on chemical reactivity at low-temperatures (down to 4 K) trigger by narrowband UV-Vis-IR radiation and using steady-state FTIR spectroscopy
Espectroscopia de fluorescência
i) fluorescência em estado estacionário ii) fluorescência resolvida no tempo
Flash Photolysis
Singlet oxygen detection and quantification.
Fotobiologia
i) viabilidade celular; ii) fototoxicidade; iii) "uptake"; e iv) mecanismo de morte celular
Infrared and Raman Spectrospcopy
Infrared and Raman spectroscopic analysis applied to materials and food science, astrochemistry, arts and cultural heritage, and fundamental science
Multivariate Statistical Analysis of Spectroscopic Data
Multivariate statistical analysis and extracting information from spectral data through chemometrics
Photoacoustic calorimetry
High precision thermochemistry studies of transient species. Quantum yields of fast photoinduced processes. Detection of fast structural volume changes in molecules and macromolecules.
Photoacoustic tomography
Based on acoustic detection of optical absorption from endogenous chromophores (e.g. hemoglobin) or exogenous contrast agents (organic dyes or nanoparticles), it is an imaging modality with great potential for preclinical research and clinical practice.
Serviços diversos de análise fotoquímica
i) estudos de fotoestabilidade incluindo avalição de fotocatalisadores, etc; ii) estudos espectroscópicos UV-Vis-NIR; iii) estudos fotofísicos; iv) estudos teóricos.
Transient Absorption Spectroscopy
Ultrafast transient absorption spectroscopy
![](https://pages.uc.pt/site/assets/files/619185/fmuc_v_fundoclaro.png)
Array-CGH
The LCG has different array resolutions in order to identify Copy number variations (CNV) and detection of loss of heterozygosity. This diagnosis can be done on pre-natal and post-natal samples.
Cryopreservation
Cryopreservation in liquid nitrogen
Developmental Disorders
LCG provides solutions in Genomics, Conventional and/or Molecular Cytogenetics and Molecular Biology for genetic studies of Developmental Disorders.
DNA extration
DNA extration from different biological samples.
Genetical family story
These studies are carried out taking into account the alterations present in the index case, using the most appropriate techniques in the set of existing LCG techniques to characterize the alterations.
High resolution banding karyotype
The study of the constitutional karyotype makes it possible to observe the entire genome, being able to identify both balanced and unbalanced structural chromosomal alterations, as well as alterations in the number of chromosomes and mosaics.
Infertility
Infertility test by Cytogentics and Molecular Biology techniques.
Lymphocyte immortalization
EBV based lymphocyte immortalization
Methylation-specific MLPA (MS-MLPA)
MS-MLPA can be used for the analysis of both methylation as well as copy number changes of syndromic related regions.
Molecular Cytogenetics - Fluorescence In Situ Hybridization (FISH)
Molecular cytogenetics (FISH) allows a more detailed study of specific chromosomal regions, increasing the resolving power of conventional cytogenetics. The LCG provides an extensive library of FISH probes.
Molecular Rapid Aneuploidy
The rapid screening of the most common aneuploidies allows, in a short period of time (24h-72h), to evaluate the ploidy (number) of chromosomes 13, 18 and 21 and of the sex chromosomes X and Y.
Multiplex Ligation-dependent Probe Amplification - MLPA
MLPA can be used for the analysis of copy number changes in DNA of syndromic related regions
Pre-natal non invasive test (NIPT)
Non invasive pre-natal test (NIPT)
Prenatal Diagnosis
The LCG performs a wide variety of exams in Prenatal. The fetal genome can be analyzed more widely, by molecular karyotype (aCGH) and constitutional karyotyope, More specific techniques like FISH, MLPA and MS-MLPA can also be performed whenever necessary.
Tissue Culture
Tissue culture of different tissues.
Training in Cytogenetics and Genomics
Annual 5-day course divided into theoretical, theoretical-practical sessions and 6 practical workshops, with the aim of addressing the evolution from cytogenetics to genomics, both in pre- and postnatal diagnosis and in research and forensic medicine
![](https://pages.uc.pt/site/assets/files/604854/captura_de_ecra_2022-11-02-_a_s_18_08_54.png)
Capacitação de equipas e indivíduos para a utilização de dados geoespaciais
Dotar os meios humanos de entidades públicas e privadas dos conhecimentos e experiência necessária para implementar soluções sustentadas assentes em dados de Observação de Terra multimissão.
Desenvolvimento de produtos de valor acrescentado a partir de dados de satélite e outras plataformas.
Apoio técnico (consultoria), co-desenvolvimento e distribuição de layers desenvolvidas in-house e por parceiros.
Formação de recursos humanos para a utilização de dados de observação da Terra multimissão
Programas de referência, atendendo às necessidades do mercado e métricas de performance internacionalmente aceites. Workshops temáticos e generalistas de capacitação em tópicos relevantes de Observação da Terra e análise de dados (e.g. machine-learning).
User characterization & engagement
Ativação de comunidades de utilizadores em mercados tradicionais (e.g. floresta, gestão do território). Mapeamento de necessidades, caracterização de territórios e comunidades, desenho e implementação (ou apoio) de ações de ‘engagement’ dos utilizadores.
![](https://pages.uc.pt/site/assets/files/549641/logotipo.png)
Cancer molecular profiles
Molecular tumour profiling can predict an individual’s prognosis by interpreting the expression pattern of a panel of tumour-related genes.
Liquid biopsy in cancer
This procedure allows to study DNA and RNA from cancer cells from a tumor that are circulating in the blood. May be used to help find cancer at an early stage and be used to help plan treatment.
Metagenomics
Investigate the microbiota composition of complex environments. This application is based on the amplification of a specific region of the 16S rRNA gene for bacteria or the ITS (Internal Transcribed Spacer) region for fungi.
Multiplex ligation-dependent probe amplification (MLPA)
This application is commonly used to identify exon-level copy number variants (CNVs) not detected by conventional sequencing.
NGS Panels
NGS panels are collections of genes that have been selected to identify a genetic cause of disease or to study regions of interest. It allows simultaneous sequencing of all the genes, in a faster and more cost-efffective way than conventional sequencing.
RNA-seq
RNA-seq allows gene expression analysis across the whole transcriptome or specifically, reveal the presence and quantity of RNA of selected genes.
Sanger Sequencing
SNVs/SNPs identification. This application is also used to identify exon-level copy number variants (CNVs).
SNVs/SNPs Genotyping
SNVs/SNPs identification.
![](https://pages.uc.pt/site/assets/files/1366958/logo.jpg)
Consultancy by GeoSedUC Services
Intervention areas
Earth Ecosystems Services
Earth Ecosystems Services - a Parternship in Rendering Services for Sedimentary Earth, Ecology and Surface waters, which integrates several technological platforms
![](https://pages.uc.pt/site/assets/files/558729/1636017942790.jpeg)
Electrofisiologia
Electrofisiologia
Imagem Animal
Imagem Animal
Neuroestimulação
Aplicação Clinica: POC, Dor, Depressão
PET/CT - Tomografia de positrões com 68Ga-DOTANOC
Aplicação Clinica: Tumores Neuroendocrinos
PET/CT - Tomografia de positrões com 11C-Beta-CIT
Aplicação Clinica: D. Parkinson
PET/CT - Tomografia de positrões com 11C-Flumazenil
Aplicação Clinica: Epilepsia
PET/CT - Tomografia de positrões com 11C-Metionina
Aplicação Clinica: Tumores Cerebrais
PET/CT - Tomografia de positrões com 11C-PK1195
Aplicação Clinica: Infecção/Inflamação cerebral
PET/CT - Tomografia de positrões com 11C-Raclopride
Aplicação Clinica: Síndromes Parkinsónicos
PET/CT - Tomografia de positrões com 13N-Amónia + 18F-FDG
Aplicação Clinica: Cardiologia
PET/CT - Tomografia de positrões com 18F-Colina
Diagnóstico em Carcinoma da Próstata
PET/CT - Tomografia de positrões com 18F-DOPA
Aplicação Clinica: Oncologia
PET/CT - Tomografia de positrões com 18F-DOPA Neurologia
Aplicação Clinica: D. Parkinson
PET/CT - Tomografia de positrões com 18F-FDG
Estudo de corpo inteiro ou cardíaco
PET/CT - Tomografia de positrões com 18F-Flureto de Sódio
Aplicação Clinica: Metastização óssea
PET/CT - Tomografia de positrões com 68Ga-PSMA
Aplicação Clinica: Carcinoma da Próstata
PET/CT - Tomografia de positrões – Estudo Cerebral c/ 11C-PiB
Aplicação Clinica: D. Alzheimer
PET/CT - Tomografia de positrões – Estudo Cerebral c/ dois marcadores: 11C-PiB + 18F-FDG
Aplicação Clinica: D. Alzheimer
Ressonãncia Magnética
Exames de Diagnóstico e Investigação
![](https://pages.uc.pt/site/assets/files/548461/captura_de_ecra_2022-10-10-_a_s_13_46_56.png)
Access to supercomputer Navigator
Access to cluster Navigator for computing, storage, visualization and data backup. Support is available to all users through a ticketing system.
Advanced Computing Courses
Organization of courses/workshops about advanced computing including: tools, libraries, resource management software, application software and accelerators.
High Performance Computing consulting
HPC consulting, namely about the existing software environment, parallel computing and usage of containers for specific workflows
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Analysis of cells and tissues to search for genetic alterations associated with tumours for personalised therapy
DNA/RNA target gene search with the Oncomine Precision Assay panel (50 genes)
Analysis of peripheral blood to search for genetic alterations associated with tumours for personalised therapy - Liquid biopsy
DNA and RNA target gene search with the Oncomine Precision Assay panel (50 genes)
DNA/RNA extraction
Isolation of nucleic acids from tissues and cells
Image analysis with/without algorithms
Analysis of areas of interest; nuclear / cytological morphometry; evaluation of immunohistochemistry techniques
Immunohistochesmistry-IHC
Immunohistochemistry (IHC) is a method of fiding antigens (e.g. proteins) in tissues by exploiting the principle of specific binding of antibodies to antigens in biological tissue.
Preparation of formalin-fixed, paraffin-embedded (FFPE) block of tissue
Standard technique to create a formalin-fixed, paraffin-embedded (FFPE) block of tissue
Qualitative Real-time PCR
Technology that comprises the entire process from paraffin-embedded tissue sample to the result (nucleic acid isolation, amplification, real-time PCR detection and data analysis) in less than three hours
Scanner of slides
Scanning of slides for digital support
Scanning of slides
Scanning of slides for digital support
Searching for regions on the chromosome by hybridization of fluorescent probes
Molecular cytogenetic technique using fluorescent probes that bind only to certain regions of a nucleic acid sequence with a high degree of complementarity.
Second opinion on requested cases
Cases from other services for a second opinion.
Slide preparation from paraffin blocks
Section of paraffin block to prepare slides for further staining
Staining of cell structures and other agents
Hematoxylin-eosin staining Test for Helycobacter Pylori
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Compressive testing of hardened concrete
Determination of the compressive strength of hardened concrete specimens.
Reaction to fire: Gross heat of combustion test
Assessment of the gross heat of combustion of products at constant volume in a bomb calorimeter.
Reaction to fire: Ignitability test
Assessment of the ignitability of products by direct small-flame impingement using vertically oriented test specimens.
Reaction to fire: Non-combustibility test
Assessment of the the non-combustibility performance, under specified conditions, of homogeneous products and substantial components of non-homogeneous products.
Reaction to fire: Radiant panel test
Assessment of the burning behaviour and spread of flame of horizontally mounted floorings exposed to a heat flux radiant gradient, when ignited with pilot flames.
Reaction to fire: Single burning item test
Assessment of the burning behaviour and spread of flame of vertically mounted specimens (in a right angle) exposed to thermal attack by a single burning item (SBI).
Tensile testing of metallic materials
Determination of the mechanical properties of metallic materials at room temperature.
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Imaging acquisition by multiphoton microscopy
Multiphoton microscopy on live or fixed samples, from different origins. Specialized technical training.
Imaging aquisition by confocal microscopy
Confocal microscopy on live or fixed biological samples, from different origins. Specialized technical training.
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Detecção de expansões em Doenças Neurológicas
Análise de expansões repetidas de nucleótidos (STR-PCR, TP-PCR)
Genotipagem da Apolipoproteína E (ApoE) para a Doença de Alzheimer
Estudo de polimorfismos (PCR e RFLP)
Painéis NGS para Doenças Neurológicas
Sequenciação de Nova Geração (NGS)
Quantificação da Progranulina no soro/plasma
Determinação dos niveis de GRN por Imunoensaio enzimático (ELISA)
Sequenciação direta de genes associados a Doenças Neurológicas
Sequenciação de Sanger
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Consultancy & Support
Data analytics; risk assessment; instrumentation; calibration; construction; geology; cartography; mitigation; remediation; Big data; others.
Gross Alpha and/or Beta
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
In situ Radon and/or toron exhalation
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Index I
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Indoor radon (Rn-222)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Polonium (Po-210)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Proportion of Biofuel
Determination of the proportion of biofuel in fuels.
Radium (Ra-226)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Radon and/or toron exhalation from samples
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Radon in water (Rn-222)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Radon sampling
Collection, preservation and transport of samples for analysis of radioactive parameters.
Sampling for Gross Alpha and/or Beta, or Total Indicative Dose
Collection, preservation and transport of samples for analysis of radioactive parameters.
Sampling for indoor radon (Rn-222)
Placement and/or collection of detectors for radon analysis.
Sampling for terrestrial radionuclides
Collection, preservation and transport of samples for analysis of radioactive parameters.
Soil gas radon
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Soil gas radon
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Specialization course in Proficiency tests in the area of ionizing radiation
At the end of the action, participants will be able to interpret the results and be aware of the most relevant aspects associated with their application in specific situations.
Terrestrial radionuclides (Ra-226, Th-232 & K-40)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Terrestrial radionuclides (Ra-226, Th-232 & K-40)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Total Indicative Dose
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
Training / Seminars / Workshops
Data analytics; Big data; mitigation; remediation; construction; risk assessment; instrumentation; calibration; geology; cartography; others.
Uranium (U-238 & U-234)
Measurement of naturally-occurring radionuclides of natural, human-made or both origins, that may pose a risk to human health.
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Ammonia analysis in liquid matrices
Ammonia Determination by Segmented Continuous Flow with Molecular Absorption Spectrometry
Análise de Carbono Orgânico Total (COT) em matrizes líquidas
Determinação de
Benthic Macroinvertebrates
Determination and identification by species of the existing benthic community in sediment samples
Nitrate analysis in liquid matrices
Determination of Nitrates by Segmented Continuous Flow with Molecular Absorption Spectrometry
Nitrite analysis in liquid matrices
Determination of Nitrites by Segmented Continuous Flow with Molecular Absorption Spectrometry
Phosphate Analysis in liquid matrices
Determination of Phosphate by Segmented Continuous Flow with Molecular Absorption Spectrometry
Silica Analysis in Liquid Matrices
Determination of Silica by Segmented Continuous Flow with Molecular Absorption Spectrometry
Stable Isotope Analysis (SIA)
Determination of Stable Isotopes by Mass Spectrometry (δ 13C (‰); δ 15N (‰); % C; % N)
Total Nitrogen Analysis in liquid matrices
Determination of Total Nitrogen by Segmented Continuous Flow with Molecular Absorption Spectrometry
Total Phosphorus Analysis in liquid matrices
Determination of Total Phosphorus by Segmented Continuous Flow with Molecular Absorption Spectrometry
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Functional studies for evaluating genetic pathogenicity
Group of methodological assays to support Functional Genomics, an integrated analysis that aims to give a functional meaning to genetic mutations, particularly new alterations and/or of unknown significance, as a cause of disease.
Genetic expression studies
Characterization of mRNA. Provides reliable and reproducible characterization of total RNA and mRNA. Objective measurement of RNA quality with RIN (RNA Integrity Number).
Study of the mitochondrial bioenergetics
The laboratory provides functional mitochondrial testing for suspected bioenergetics disorders.
Study of the mitochondrial genome
Allows identification of alterations in mitochondrial DNA, which may elucidate disease and bioenergetics dysfunction. Mitochondrial biology and pathophysiology is a complex field of research, which may help to answer a broad range of questions.
Study of the nuclear genome
Sequencing of whole nuclear exome or individual genes (in familial/trio or individual), including bioinformatics analysis for pathogenicity evaluation. Confirmation of specific mutations.
Theranostics Studies in Precision Medicine
Study of genes associated to pharmacogenomics. Study of biochemical biomarkers, like those associated to wellness.
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Carbon coating of samples for SEM imaging/analysis
Revestimento por película de cabono de amostras para análise/imagem por microscopia eletrónica de varrimento SEM
Characterisation of thin films and coatings by Grazing Incidence X-ray diffraction (GIXRD)
Aquisição de difratogramas de RX em materiais policristalinos (pó) à temperatura ambiente para identificação de fases, quantificação ou refinamento estrutural pelo método de Rietveld.
Electric transport properties (ETO)
Measurement of electrical transport properties (resistivity, Hall effect, I(V) e dI/dV) in the temperature range 1.8 K-400 K and magnetic field 0-9 T.
Elemental quantitative analysis by mass spectrometry (ICP-MS)
Elemental quantitative analysis by mass spectrometry (ICP-MS) in diluted aqueous solutions
Imaging by Electron Scanning Microscopy (SEM)
Imaging by Electron Scanning Microscopy (SEM)
Measurement of the thickness of thin films by X-ray fluorescence (XRF)
Measurement of the thickness of thin films and coatings by X-ray fluorescence (XRF)
Metallic coating of SEM samples by sputtering
Metallic coating of samples for SEM imaging/ analysis by sputtering
Powder X-ray diffraction (XRD) at room temperature
Obtenção de imagem por microscopia de força atómica (AFM)
Powder X-ray diffraction (XRD) at room temperature (XRD)
Aquisição de difratogramas de RX em materiais policristalinos (pó) à temperatura ambiente para identificação de fases, quantificação ou refinamento estrutural pelo método de Rietveld.
Powder X-ray diffraction (XRD) at room temperature (XRD)
Medidas de magnetização em função da temperatura (1.8-400K) e campo magnético aplicado (0-9T) pela técnica VSM
Powder X-ray diffraction (XRD) at room temperature (XRD)
Medição de propriedades de transporte térmico
Powder X-ray diffraction (XRD) at room temperature (XRD)
Aquisição de difratogramas de RX em materiais policristalinos (pó) a temperatura variável (ambiente - 1450 ºC) para identificação de fases, quantificação ou refinamento estrutural pelo método de Rietveld.
Powder X-ray diffraction (XRD) at room temperature (XRD)
Fornecimento de ácido nítrico ultra-puro, obtido por destilação em sub-eubição, para uso em preparação de amostras para análise por ICP-MS
Powder X-ray diffraction (XRD) at room temperature (XRD)
Aquisição de perfis de refletometria de RX (XRR) para caracterização de filmes finos e revestimentos (espessura do filme, rugosidade, etc.)
Simultaneous Thermal Analysis (STA) - Thermogravimetry (TG) + Differential Scanning Calorimetry (DSC)
Medição simultânea de variação de entalpia e de massa, em processos de aquecimento e arrefecimento, entre 20 e 1000 ºC para estudo e caracterização termodinâmica de transições de fase, decomposição térmica, etc.
Specific heat measurement (Cp)
Specific heat measurements as function of temperature and applied magnetic field.
Torque Magnetometry (TqM)
Medidas de magnetização em função da temperatura (1.8-400K) e campo magnético aplicado (0-9T) pela técnica de magnetometria de torque
X-ray Fluorescence Analysis (XRF) via Energy Disersive Spectroscopy EDS
Obtenção de espectros de fluorescência de raios-X por excitação de feixe eletrónico (espectroscopia EDS)
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1D 13C-NMR Spectrum
Acquisition of 13C-NMR Spectrum
1D 1H-NMR Spectrum
Acquisition of 1H-NMR spectrum.
2D 1H-NMR Spectra
Acquisition of 2D homonuclear NMR spectra
2D heteronuclear NMR spectra
Acquisition of 2D heteronuclear NMR spectra
NMR spectra of less common nuclei (2H, 11B, 19F, 31P, 195Pt, etc)
Acquisition of 1D NMR spectra for less common nuclei
Quantitative 1H-NMR spectroscopy
1D 1H-NMR spectrum with absolute quantification of main species
Structural analysis of small molecules
Assignment of 1D and 2D NMR spectra and structure determination of small molecules from different origins
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Consultoria em Saúde Mental
Serviços de consultoria especializada, nas áreas da saúde mental e do bem-estar, destinados a diferentes equipas, organizações e serviços.
Formação em Psicologia Clínica Cognitivo-Comportamental
Cursos de formação para a capacitação e desenvolvimento de diferentes profissionais na área da saúde mental.
Intervenção clínica em Saúde Mental
Serviços de prevenção e tratamento da doença mental e de promoção do bem-estar emocional (Psicologia Clínica Cognitivo-Comportamental e Psiquiatria).
Supervisão clínica de psicólogos
Serviços de supervisão clínica especializada para psicólogos.
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Analysis of Fatty Acids (GC, MIDI)
Bacterial Fatty Acids identification and quantification by Gas Chromatography using the standard MIS Library Generation Software (Sherlock Microbial ID System).
Analysis of Polar Lipids (TLC)
Analysis of Polar Lipids from bacterial strains by Thin Layer Chromatography.
Analysis of Respiratory Quinones (HPLC)
Analysis of Respiratory Quinones from bacterial strains by High Performance Liquid Chromatography.
Bacterial Strains from Public Collection
Bacterial Strains from Public Collection: Active cultures | Freeze-dried strains
Beer Analysis
Bacteria detection on WLD selective medium | Bacteria identification | Hemocytometer yeast cell count | Beer specific gravity at 20 °C | pH | Total acidity | Color on SRM scale | Color on EBC scale | Beer bitterness | Total reducing sugars
Biochemical Analysis
Analysis of fatty acids (GC, MIDI) | Analysis of polar lipids (TLC) | Analysis of respiratory quinones (HPLC)
Bioinformatic Services
Whole genome analysis | Phylogenomic analysis
Deposit of Bacterial Strains
Public Deposit | Safe Deposit | Renew the Safe Deposit Service | Annual Maintenance Fee | Release of Strain
Identification and Characterization
Genomic DNA Extraction | Sequencing of 16S rRNA gene | Phylogenetic analysis | Sequence Analysis of Genes | Mol% G+C Content Analysis of Genomic DNA | RAPD Fingerprinting for two Strains | Whole Genome Sequencing of one Prokaryotic strain
Isolation and Preservation
Isolation from a mixed culture plate | Preservation in −80 °C
Microbial Diversity
Denaturing Gradient Gel Electrophoresis (DGGE) | Phospholipid Fatty Acid Analysis (PLFA) | Barcoding Sequencing
Other Services
Multiproposes certificates (not related with describing of novel species) | Consultancy | Training and related services
Phenotypic Characterization
Basic Phenotypic Characterization (based on API® strips) | BIOLOG Microplates (for extensive testing of oxidation of different carbon sources) | Morphological study (celular morphologyl, Gram, KOH, catalase, oxidase)
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Consultancy & Support
Plasmid design; Cloning; Vector design and engineering; Purification processes; Chromatography; Clean rooms; Instrumentation; Gene therapy; Cell models; Animal models; Disease models; Assays; Preclinical studies; Data analysis; Others.
Isolation of Extracellular Vesicles / Exosomes from biological fluids
Isolation of Extracellular Vesicles / Exosomes from diferent biological fluids
Production and Purification of Adeno-associated viral vectors (AAVs)
Production of highly pure AAVs (AAV1, AAV2, AAV5, AAV6, AAV8, AAV9, PhP.eB) using an optimized platform based on high performance liquid chromatography.
Production and Purification of Lentiviral vectors (LVs)
Production of highly pure lentiviral vectors using an optimized platform.
Production and Purification of modified exosomes
Production of modified exosomes - extracelular vesicles (EVs)
Titration and Characterization of NON-VIRAL PARTICLES
Measurement and Characterization of non-viral vectors (Extracellular vesicles / Exosomes) in various types of samples using a diferent set of assays.
Titration and Characterization of VIRAL particles
Measurement of viral vector titer (AAV, LV, vesoxome) in various types of samples using a diferent set of assays.
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Análise microbiológica de alimentos prontos para consumo e de matérias-primas
Parâmetros a analisar: Microrganismos viáveis a 30ºC Listeria monocytogenes e Listeria spp. Salmonella spp. Enterobacteriaceae Bacillus cereus Staphylococcus aureus Campylobacter spp. Escherichia coli Clostridium perfringens Bolores e leveduras
Análise microbiológica de mãos de manipuladores de alimentos
Parâmetros a analisar Microrganismos viáveis a 30ºC Staphylococcus aureus Escherichia coli
Análise microbiológica de superfícies de ambiente de preparação/distribuição alimentar
Parâmetros a analisar: Microrganismos viáveis a 30ºC Listeria monocytogenes e Listeria spp. Enterobacteriaceae Staphylococcus aureus Escherichia coli Bolores e leveduras
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Access to Widefield and Confocal Microscopes
Widefield Microscope with LED-based system (UV 385/30 nm, B 469/38 nm, G 555/30 nm, Y 590/27 nm, and R 631/33 nm) Scanning Confocal Microscope with 4 laser units (Diode 405 nm; Argon/2: 458, 488, 514 nm; DPSS: 561 nm and HeNe: 633 nm)
Microscopy Analysis by Light or Electron Microscopy
Observation and analysis of live or fixed samples.
Microscopy Course
Theoretical and practical training in optical and/or electron microscopy
Sample Processing for Electron Microscopy
The iLAB performs and provides the required materials and equipments necessary for sample processing for electron microscopy including fixation, dehydration, resin embedding and ultramicrotomy.